Changes of CD8~+CD28~+ and CD8~+ CD28~-T cell in PBMCs of children with asthma

Objective To study clinical significance and immunity functional of T-lymphocyte subgroups in children with asthma by to associated delection of CD4,CD8 and CD28.Methods CD3 +,CD4 +,CD8 +,CD8 +CD28 +,CD8 +CD28 - cell in peripheral blood were measured by the flow cytometry in children with asthma.Results CD3 +,CD4 +,CD8 +,CD28 - cells were significantly lower in children with asthma group than in control group(P0.01、P0.05),CD8 +CD28 + cell were higher than in control group(P0.05),the rate of CD4 +/CD8 +,CD8 + cell had no significantly changes comparing with that in control group(P0.05).Conclusion There is a disorder of T-lymphocyte immune function in children with asthma.The imbalance between CD8 +CD28 + cell and CD8 +CD28 - cell may be one of the factor for the disorder of the bady's immune function.