2011•Guoji yiyao weisheng daobaoRequires access
A study on immunologic function in children with bronchial asthma
Cai Xing-sheng, YU Hua-fei, Yong-hin Zhu, Hang Chun, Chen Youjia
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Abstract
Objective To investigate the immune function of children with asthma for offering scientific evidence of immunological regulation in treatment children with asthma,. Methods Total-Ig, IgG,IgA, IgM, IgE, CD3, CD4, CD8, CD4/CD8 were detected in 77 cases with asthma. The results were compared with normal value of children of the same age in our hospital. The correlations were analyzed between CD3,CD4, CD8, CD4/CD8 with IgG, IgA, IgE. Results Total-Ig, IgC, IgA, CD4, CD4/CD8 were significantly lower in children with asthma than that of normal value(P＜0.01, respectively), CD3, CD8 were lower in children with asthma than normal value(P＜0.05, respectively), IgE was significantly higher in children with asthma than normal value(P＜0.01), IgM had no significant difference ( P＞0.05). There were positive correlation between CD3 with Total-Ig, IgG, IgA(P＜0.05). There were significant positive correlation between CD4, CD4/CD8 with Total - Ig, IgG, IgA(P＜0.01). There were significant negative correlation between CD8, CD4/CD8 with IgE (P＜ 0.01). Conclusion There were cellular immune functional defect and humoral immune functional disorder in children with asthma. Adjusting the immune function should be emphasized in treatment to children with asthma.
Key words:
Asthma; Children; T lymphocyte subsets; Immunoglobulin