Pathogens from urine culture and drug resistance

OBJECTIVE To investigate the distribution and drug resistance of the pathogenic bacteria causing urinary tract infections during 2009-2011 so as to provide evidence for reasonable clinical use of antibiotics.METHODS VITEK-2 system was used to identify the pathogens,the drug susceptibility testing was performed,then the results were assessed by CLSI 2008 standards,and statistical analysis was conducted with the use of WHONET5.6 software.RESULTS A total of 4976 clinical isolates of pathogens were isolated from urine culture,including 1325(26.63%)strains of gram-positive cocci,2861(57.49%)strains of gram-negative bacilli,and 790(18.88%)strains of fungi;Escherichia coli(31.17%),Enterococci(13.77%),Candida albicans(8.98%),coagulase-negative Staphylococcus(7.94%),and Klebsiella pneumoniae(7.58%)ranked the top 5 species of pathogens isolated.The gram-positive cocci were highly resistant to the commonly used antibiotics but remained susceptibility to linezolid and vancomycin,and no strains resistant to linezolid were found;the gram-negative bacilli have produced certain drug resistance to the commonly used antibiotics,the drug resistance rates of such non-fermenting bacteria as Acinetobacter baumannii and Pseudomonas aeruginosa to imipenem were 54.5% and 36.3%,respectively.The detection rate of the ESBLs-producing E.coli was 48.3%,the ESBLs-producing K.pneumoniae 45.1%,and the Proteus mirabilis(42.3%),all of which showed an upward trend.CONCLUSION It is of great significance for the control of spread of drug resistant strains and for the reasonable use of antibiotics to accurately analyze the distribution and drug resistance of the pathogens causing urinary tract infections.