Distribution and antibiotics resistance of pathogens causing urinary tract infections in tumor patients

OBJECTIVE To investigate the distribution and drug resistance of pathogenic bacteria causing urinary tract infections in tumor patients so as to provide basis for clinical treatment of urinary tract infections.METHODS By means of disk diffusion K-B method,the drug susceptibility testing was performed for the pathogens isolated from the urine specimens from Jan 2008 to Dec 2011,and the data were analyzed by WHONET 5.4 software.RESULTS Totally 359 strains of pathogens were isolated from the urine specimens of the patients who enrolled the hospital during 2008-2011,among which there were 148(41.2%) strains of Escherichia coli,55(15.3%) strains of Klebsiella pneumoniae,39(10.9%) strains of coagulase-negative Staphylococcus,31(8.6%) strains of Enterococcus,24(6.7%) strains of yeast-like fungi,and 19(5.3%) strains of Pseudomonas aeruginosa.The drug resistance rates of E.coli and K.pneumoniae to cefoperazone-sulbactam,piperacillin-tazobactam and amikacin were less than 20.0%,the drug resistance rates to nitrofurantoin were 8.8% and 52.8%,respectively,and the strains were highly sensitive to imipenem.The P.aeruginosa strains were sensitive to imipenem and amikacin,and the drug resistance rates to penicillin,ampicillin and nitrofurans were less than 20.0%.The resistance rates of E.faecali strains were lower than 20.0%,while the resistance rates of the E.faecium strains were higher than 60.0%.The coagulase-negative Staphylococcus strains were sensitive to nitrofurans.Except one strain of Enterococcus gallinarum naturally resistant to vancomycin,there were no strains of gram-positive cocci resistant to glycopeptide.CONCLUSION The gram-negative bacilli are the major pathogenic bacteria causing urinary tract infections.The drug resistance rates of the clinical isolates to most of the commonly used antibiotics keep an upward trend.It is of great significance to pay attention to the monitoring of pathogens and to reasonably use antibiotics.