2008•Tianjin Yike Daxue xuebaoRequires access
The prognostic value of Tirofiban in patients with acute myocardial infarction after primary percutaneous coronary intervention
Yuming Li
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Abstract
Objective: To investigate the effect of glycoprotein IIb/IIIa receptor blockade tirofiban on microvascular flow and survival in patients with ST-segment elevated myocardial infarction (STEMI)after primary percutaneous coronary intervention(PCI). Methods: A total of 119 patients with STEMI underwent primary PCI which had angiographic evidence of initial total occlusion of infarct-related artery and finally restored to TIMI 3 flow after PCI were divided into the tirofiban group(n =51) and the control group (n =68). TMPG after PCI, the resolution of the sum of ST-segment elevation at 60 minutes after PCI , and cardiac function 1 week after PCI were assessed. The bleeding complications were also assessed. Results: (1)Baseline clinical and angiographic characteristics of the two groups were similar. (2) TIMI myocardial perfusion grade (TMPG) 0-1 grade rate after PCI was lower in tirofiban group(P0.05),3 grade rate after PCI was higher in tirofiban group(P0.05).(3)There were less frequently complete ST-segment resolution in tirofiban group than that in control group.(4)LVEF was higher in tirofiban group than that in control group (P0.05). (5)There were slightly more minor bleeding complications in the tirofiban group compared with the control, but had no difference in statistics. Conclusion: Tirofiban can ameliorate microvascular perfusion and cardiac function of patients with STEMI undergoing primary PCI.