Clinical study on Xuebijing Injection combined with imipenem in treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis

Objective To explore clinical efficacy of Xuebijing Injection combined with imipenem in treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis. Methods Patients(88 cases) with liver cirrhosis complicated with spontaneous bacterial peritonitis in Huanghe Sanmenxia Hospital from August 2013 to August 2015 were randomly divided into control and treatment groups, and each group had 44 cases. The patients in the control group were administered with abdominal puncture, and drainage was less than or equal to 2000 m L/d, and they were given Imipenem and Cilastatin Sodium for injection 0.5 g/time after liquid discharge, once daily. The patients in the control group were iv administered with Imipenem and Cilastatin Sodium for injection, 0.5 g added into 0.9% normal saline 100 m L, three times daily. The patients in the treatment group were iv administered with Xuebijing Injection, 50 m L added into 0.9% normal saline 100 m L, once daily. The patients in two groups were treated for 7 d. After treatment, the efficacy was evaluated, and disappeared time of clinical symptoms such as fever, abdominal distension, abdominal pain, abdominal tenderness, and back pain in two groups were compared. The incidence of complications in two groups was observed, and the changes of WBC, CRP, PCT, TNF-α, and IL-6 in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 75.00% and 90.91%, respectively, and there were differences between two groups(P 0.05). Disappeared times of clinical symptoms such as fever, abdominal distension, abdominal pain, abdominal tenderness and back pain in two groups were shorter than those in control group, with significant difference between two groups(P 0.05). WBC, CRP, PCT, TNF-α, and IL-6 were significantly reduced, and the difference was statistically significant in the same group(P 0.05). After treatment for 7 d, the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P 0.05). The incidence of complications in the control and the treatment groups were 18.18% and 4.55%, with significant difference between two groups(P 0.05). Conclusion Xuebijing Injection combined with imipenem has clinical curative effect in treatment of liver cirrhosis complicated with spontaneous bacterial peritonitis, and can significantly relieve the clinical symptoms, also can reduce the incidence of complications, while can reduce the expression of serum inflammatory cytokines, which has a certain clinical application value.