Clinical efficacy of abdominal paracentesis combined with imipenem injection in the treatment of spontaneous bacterial peritonitis in patients with liver cirrhosis

Objective To observe the clinical efficacy of abdominal paracentesis combined with imipenem injection in the treatment of spontaneous bacterial peritonitis in patients with liver cirrhosis.Methods Sixty-two liver cirrhosis patients with spontaneous bacterial peritonitis were divided into treatment group(32 cases) and control group(30 cases).Control group was treated with abdominal paracentesis and intravenous imipenem;in addition to the treatment of control group,the treatment group was treated with intraperitoneal injection of imipenem.The treatment time was 7 days in both groups.The clinical efficacy,clinical symptoms and signs in two groups were observed after treatment.Results Compared with control group,the total efficiency(75.0% vs.60.0%) was significantly increased(P 0.05) and the mortality rate(9.4% vs.20%) were significantly decreased in treatment group(P 0.05);the clinical symptoms and signs in treatment group were also relieved significantly(P 0.05).Conclusion Abdominal paracentesis combined with imipenem injection is effective and significantly reduces mortality in the treatment of spontaneous bacterial peritonitis in patients with liver cirrhosis.