Observation on the therapeutic effect of Jiawei Huangqin Tang on the prevention of delayed diarrhea caused by Irinotecan-based chemotherapy at the late stage of colorectal cancer

Objective To explore the preventative actions of Jiawei Huangqin Tang on delayed diarrhea caused by Irinotecan( CPT-11)-based chemotherapy. Methods 72 FOLFIRI chemotherapy treated patients were randomly divided into a prevention group of 34 and a control group of 38. The control group received standard FOLFIRI chemotherapy only,while the prevention group began to orally take Jiawei Huangqin Tang one day before chemotherapy altogether for one week. Then,the occurrence rate and severity of diarrhea,the occurrence rate of chemotherapy course changes,and the occurrence rate of adverse reactions in both groups were observed. Results The occurrence rate of diarrhea,chemotherapy course changes,nausea and vomiting in the prevention group were all lower than that in the control group,the difference was statistically significant( P 0. 05). Conclusion Jiawei Huangqin Tang can prevent delayed diarrhea caused by CPT-11 chemotherapy,reduce the occurrence of nausea and vomiting,increase the compliance for chemotherapy regimen,and improve the quality of life of patients with advanced colorectal cancer during chemotherapy.