Therapeutic effect of long-term application of aldosterone antagonist in aged patients with chronic heart failure

Objective:To explore curative effect of long-term application of aldosterone antagonist(spironolactone) in aged patients with chronic heart failure(CHF).Methods:A total of 120 CHF cases were randomly divided into spironolactone group(n=66,received spironolactone 20 mg/d,based on routine anti-heart failure drug therapy) and CHF routine treatment control group(n=54);changes of left ventricular mass index(LVMI),left ventricular ejection fraction(LVEF) and BNP level before and three months after treatment were measured,compared and analyzed in two groups.Results:Total effective rate of cardiac function improvement(80%) of spironolactone group was significantly higher than that of CHF routine treatment control group(9.25%),P0.05;compared with CHF routine treatment control group,there were significant decrease in LVMI [(340.7± 68.3) g/m2 vs.(179.6±33.3) g/m2] and BNP level [(366.15±23.36) pg/ml vs.(330.38±11.56) pg/ml],and significant increase in LVEF [(34.11 ±2.71)% vs.(46.2±3.9)%] in spironolactone group after three months treatment,P0.05 all.Conclusion:Based on routine anti-heart failure drug therapy,aldosterone antagonist can decrease BNP level,inhibit ventricular remodeling,effectively improve heart function.