2012•Journal of Clinical Medicine in PracticeRequires access

Effect of spironolactone on the cardiac function and plasma brain natriuretic peptide(BNP) in elderly patients with chronic heart failure

S N Yang

Abstract

Objective To investigate the role of spironolactone in the treatment of chronic heart failure.Methods Sixty-two patients with chronic heart failure were divided into conventional group(n=30) and spironolactone group(n=32).The conventional group received ACEI,digitalis, thiazide diuretics,β-blockers and other conventional treatments.Spironolactone group took oral spironolactone treatment in addition to the conventional treatment.Serum BNP levels,LVEF and VE/VA before and after 4 months of the treatment were observed.The treatment efficacy after 1 month of the treatment was observed as well.Results One month after treatment,the total efficiency(90.6%) of spironolactone group was significantly higher than that of the conventional group(70%).LVEF and VE/VA of spironolactone group were significantly higher than those of the conventional group(P0.05).After treatment,the serum BNP levels of both groups decreased.The spironolactone group had more significant decreases(P0.05).Conclusion Spironolactone can significantly improve cardiac function and decrease serum BNP levels in elderly patients with chronic heart failure.

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Key concepts: Spironolactone, Medicine, Heart failure, Ejection fraction, Internal medicine, Digitalis, Cardiology, Brain natriuretic peptide