Clinical effects observation of perindopril combined with spironolactone in treating chronic heart failure

Objective:To observe the effects of combination using of perindopril and spironolactone on heart function and brain natriuretic peptide(BNP)of chronic heart failure(CHF).Methods:84 patients with CHF were randomly divided into treatment group and control group.On the basis of conventional therapy,the treatment group was added with perindopril(4 mg once daily) and spironolactone(20 mg once daily).The heart function,left ventricle ejection fraction,serum BNP and adverse effects were observed before and after treatment.Results:The total effective rate of heart function in treatment group was 71.4% and 52.4% in control group.Left ventricle ejection fraction of two groups was obviously elevated after treatment,and the increment of treatment group was more significant.Serum BNP was obviously decreased(P0.01).Conclusion:The long-term clinical therapeutic effect of combination using of perindopril and low dose of spironolactone on chronic heart failure is predominant with safe in use.