Effects of Simvastatin on the Expression of Vascular Endothelial Growth Factor in Human Umbilical Vein Endothelial Cell

Aim To investigate the effect of simvastatin on the expression of vascular endothelial growth factor (VEGF) and its receptor in cultured human umbilical vein endothelial cell. Methods The effects of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and simvastatin on the levels of VEGF and its receptor in human umbilical vein endothelial cell were studied by means of reverse transcription polymerase chain reaction and Western Blot. Results TNF-α and IL-1β significantly increased the expression of VEGF and its receptor in human umbilical vein endothelial cell,which were decreased by Simvastatin at the different levels. Conclusion Simvastatin may have the effects of anti-inflammation and anti-atherosclerosis.