The expression and significance of NET-1 and VEGF in lung cancer

Objective To explore the expressions and clinical significance of NET-1 and VEGF in lung cancer.Methods Immunohistochemical streptavidin-peroxidase (SP) technique was used to examine the expressions of NET-1 and VEGF in 120 human lung cancer specimens and in 10 normal lung tissues.Results The positive rates of NET-1 and VEGF in lung cancer (85.00% and 55.83%) were significantly higher than those in the normal tissue (40.00% and 0.00%),and the difference was statistically significant(P0.05).NET-1 and VEGF expressions were not correlated with age,sex and tumor position (P0.05);the positive expression rates of NET-1 and VEGF were related to differentiation,clinical stage and lymph nodes metastasis (P0.05).Conclusion The expressions of NET-1 and VEGF were positively related to the lung cancers'differentiation,clinical stage and lymph nodes metastasis,and the levels of their expressions in lung cancer tissues were more higher than that in normal lung tissues,which means they could promote the tumor cells'transformation,multiple and moving and be an useful tool for providing information about the malignant degree.