2003•Chengde Yixueyuan xuebaoRequires access

EXPRESSION OF P53 AND VEGF IN LUNG CANCER AND THEIR CLINICAL SIGNIFICANCE

Xing Shen

Abstract

Objective:To explore the relationship between expression of VEGF and pathological factors.Methods:The expression of VEGF were detected in 47 lung cancer lesions,10 cases normal lung tissues by immunohistochemical staining(SP).Results:VEGF expressions were significantly higher in lung cancer than those in normal tissues(P0.01).The expression of VEGF in lung cancer was closely related to differentiation grade(P0.05),lymph node metastasis and P TNM stages,but not related to sex,age,tumor size and histological types(P0.05).Conclusion:VEGF expressions in lung cancer is helpful to evaluate the biological behavior of lung cancer,and served as a valuable factor for estimating patients prognosis.

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Key concepts: Lung cancer, Immunohistochemistry, Pathological, Medicine, Pathology, VEGF receptors, Lung, Lymph node metastasis