Expressions and clinical significances of p53 and VEGF in lung cancer

OBJECTIVE: To investigate the relationship between p53,VEGF and the clinicopathologic characteristics of lung cancer. METHODS: A total of 170 specimens of lung cancer were examined for p53 and VEGF by the immunohistochemical staining. RESULTS: Positive rates of p53 and VEGF were 48.8% and 47.6% respectively. The relationship between the expressions of p53 and VEGF and sex, age and histological type of lung cancer patients showed no statistical significance, P0.05. p53 and VEGF were closely related to lymph node metastasis, invasions of the lesions and pTNM stage of lung cancer,P0.05(P=0.026, 0.002,0.012). p53 was related to the size of primary cancer and cell differentiation, P0.05(P=0.003, 0.037). while VEGF was unrelated to these items, P0.05 ( P=0.871, 0.677). CONCLUSION: p53 and VEGF play an important role in the oncogenesis and development of lung cancer and can be regarded as biological markers for lung cancer.