Changes of Serum Endotoximia,TNF-α and Interleukin-6 Levels and Effective in Preventing Spontaneous Bacterial Peritonitis after Treatment combined with Beifeida and Lactulose in Patients With Liver Cirrhosis

[Objective] To observe the changes of serum endotoxin and TNF-α,interleukin-6 levels before and after treatment combined with beifeida and Lactulose in patients with liver cirrhosis and to observe the incidence of spontaneous bacterial peritonitis(SBP)and to find a method that can more efficient to reduce the incidence of SBP.[Methods]100 hundred patients were included in the study.Patients in controll Group A(n=50)were given conventional treatment such as protecting the liver,supplement human albumin and uragogue.Patients in treament Group B(n=50)were given both beifeida tid po and Lactulose bid po on the basis of conventional treatment for three months.[Results]Serum endotoxin,TNF-αand interleukin-6 levels in Group A were not significantly changed after treatment,but SBP incidence was higher than Group B.At Group B,serum endotoxin,TNF-α,interleukin-6 levels and SBP incidence significantly droped,the difference was significant at statistics as compared with Group A.[Conclusion] The treatment combined with beifeida and Lactulose can effectively reduce serum endotoxin,TNF-α and interleukin-6 levels,and also can significantly reduce the incidence of SBP.