The clinical effect of lactulose and bifid lriple viable on intestinal barrier function and inflammatory cytokine in cirrhosis patients with spontaneous bacterial peritonitis

Objective To evaluate the effects of lactulose and bifid lriple viable on intestinal barrier function,serum and ascites TNF-α,interleukin-6 levels in hepatitis cirrhotic patients with spontaneous bacterial peritonitis(SBP).Methods One hundred and twenty SBP patients with hepatitis cirrhosis were randomly allocated into two groups,treatment group(n = 60) and control group(n =60).Health volunteers were selected as healthy control group(n =30).All subjects were observed for 7days.To evaluate intestinal permeability,the concentration of lactulose(LAC) and mannitol(MAN) in urine was measured using high pressure liquid chromatograph with refractive index detector(HPLC RID),the concentration of serum and ascites TNF-αand interleukin-6 were measured before and after seven days of treatment with lactulose and bifid lriple viable, and mortality rate of patients was counted.Results The levels of urinary excretion of LAC/MAN ratios,serum and ascites TNF-αand interleukin-6 levels in treatment group and control group were significantly higher than of healthy control group (P0.05 or P0.01);the levels of urinary excretion of LAC/MAN ratios,serum and ascites TNF-αand interleukin-6 levels after treatment in treatment group were significantly lowered than that of control group(P0.05 or P0.01 );the mortality rate of treatment group was significantly lowered than that of control group(8.33%vs 18.33%,P0.05).Conclusion The treatment combined with lactulose and bifid lriple viable can effectively reduce serum and ascites TNF-αand interleukin -6 levels,improve intestinal barrier function and prognosis.