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The Comparative Study of Olazepine and Risperidone in the Clincal Treatment of Schizophrenia with Predominantly Negative Symptoms

Wang Zeng-xua

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Abstract

Objective To assess the efficacy and safety of olazepine and risperidone in the treatment of schizophrenia with predominantly negative symptoms. Methods 70 schizophrenia patients with predominantly negative symptoms were randomly assigned to olazepine group(n=35) and risperidone group(n=35) for 12 weeks. The efficacy and side effects were evaluated with positive and negative symptom scale(PANSS) and treatment emergent symptom scales(TESS). Results There was no significant difference in efficacy between the two groups(74.2% vs 71.4%, P0.05). Both groups had no significant difference in the overall adverse reactions(37.1%, 34.2%, P0.05). Conclusion Olazepine is effective and safe in treatment of negative symptoms of schizophrenia as risperidone.

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What this paper is about

Objective To assess the efficacy and safety of olazepine and risperidone in the treatment of schizophrenia with predominantly negative symptoms. Methods 70 schizophrenia patients with predominantly negative symptoms were randomly assigned to olazepine group(n=35) and risperidone group(n=35) for 12 weeks. The efficacy and side effects were evaluated with positive and negative symptom scale(PANSS) and treatment emergent symptom scales(TESS). Results There was no significant difference in efficacy between the two groups(74.2% vs 71.4%, P0.05). Both groups had no significant difference in the overall adverse reactions(37.1%, 34.2%, P0.05). Conclusion Olazepine is effective and safe in treatment of negative symptoms of schizophrenia as risperidone.

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Available abstract

Objective To assess the efficacy and safety of olazepine and risperidone in the treatment of schizophrenia with predominantly negative symptoms. Methods 70 schizophrenia patients with predominantly negative symptoms were randomly assigned to olazepine group(n=35) and risperidone group(n=35) for 12 weeks. The efficacy and side effects were evaluated with positive and negative symptom scale(PANSS) and treatment emergent symptom scales(TESS). Results There was no significant difference in efficacy between the two groups(74.2% vs 71.4%, P0.05). Both groups had no significant difference in the overall adverse reactions(37.1%, 34.2%, P0.05). Conclusion Olazepine is effective and safe in treatment of negative symptoms of schizophrenia as risperidone.

Key concepts: Risperidone, Medicine, Schizophrenia (object-oriented programming), Negative symptom, Internal medicine, Significant difference, Adverse effect, Psychiatry

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The Comparative Study of Olazepine and Risperidone in the Clincal Treatment of Schizophrenia with Predominantly Negative Symptoms — Research Paper | ScholarLens