Evaluation of Atorvastatin in the Different Intensive Time and Dosage on Plasma Levels of hsCRP、Lipid and Cardiovascular Events in Patients with Acute Coronary Syndrome

【Objective】To observe the influence of atorvastatin in the different intensive time and dosage on clinical effects in patients with acute coronary syndrome(ACS).【Methods】Seventy-eight patients of ACS were randomly assigned into three groups:A group(n=26)was given 20 mg/d atorvastatin at night,B group(n=26) was given 40 mg/d atorvastatin at night,C group(n=26) was given 40 mg/d atorvastatin at night first week,then 20 mg/d atorvastatin at night.Plasma levels of hsCRP、lipid were detected before and 1,6 weeks after treatment and the cardiovascular events were recorded in 6 weeks in all patients.【Results】At 1 week after treatment,the plasma levels of lipid did not change significantly(P0.05)in any group,the plasma level of hs-CRP was markedly reduced in B group and C group(P0.05),but was not markedly reduced in A group(P0.05),at 6 weeks after treatment,compared to those before treatment,the plasma levels of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglycerid(TG),hs-CRP decreased significantly.B group and C group compared to A group,showed significant difference on plasma levels of hsCRP 、TC、TG and cardiovascular events(P0.05),but there was not significant difference between B group and C group(P0.05).【Conclusion】Efficacy of treatment with high-dose atorvastatin first and then low-dose is better than continual low-dose and similar to continual high-dose.