The short-term effect of different dose of atorvastatin on inflammatory factors in patients with acute coronary syndrome

OBJECTIVE To observe the influence of different dose of atorvastatin on IL-6 and CRP in patients with acute coronary syndrome (ACS) within the first 3 days after the coronary events. METHODS Seventy-one patients with ACS were divided randomly into atorvastatin 40 mg group, atorvastatin 20 mg group and control group. Levels of IL-6 , CRP and lipid were detected before and after treatment. RESULTS Levels of lipid were not changed significantly in the three groups ( P 0.05 ). Levels of Il-6 and CRP decreased significantly in both atorvaststin 40 mg group and atorvaststin 20 mg group than these in the control group ( P 0.05 ), but these changes were more significant in the atorvaststin 40 mg group than in the atorvastatin 20 mg group ( P 0.05 ).CONCLUSION Atorvastatin could decrease the levels of inflammatory factors in patients with ACS within the first 3 days after the attack of this coronary event. Therefore it may be benefit to stabilize atherosclerotic plaque.The higher dose,the more benefit.