Effects of atorvastatin on serum high-sensitivity c-reactive protein level in patients with acute coronary syndrome

Objective To explore effects of atorvastatin with different doses on serum high-sensitivity c-reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods 122 patients with ACS in Wuhan General Hospital of Guangzhou Military from May 2010 to May 2012 were randomly divided into atorvastatin strength group(40 mg/d,n=41),atorvastatin treatment group(20 mg/d,n=41),and control group(taking nitrate and angiotensin converting enzyme inhibitors or beta blockers conventional treatment,n=40).Serum hs-CRP levels of the three groups were measured and compared within 24 h after admission and 2 weeks after therapy.Results After 2 weeks treatment,the 3 group′s serum hs-CRP levels were apparently decreased compared with before treatment(P0.05),in which,in terms of serum hs-CRP level,atorvastatin treatment group was significantly decreased than control group(P0.05),atorvastatin strength group was significantly decreased than atorvastatin treatment group and control group(P0.05).Conclusion Atorvastatin could reduce inflammatory reaction of atherosclerotic plaque in ACS patients,and taking large dose of atorvastatin could decrease hs-CRP level.