Effect of Telmisartan on metabolic syndrome correlation factor of OLETF rats fed with high-fat diet

【Objective】 To investigate the effect of Telmisartan on metabolic syndrome correlation factor in OLETF rats fed with high-fat diet.【Methods】 According to OGTT 2 h and body weight,forty-eight OLETF rats were randomly divided into five groups: Telmisartan(group L),combination of Telmisartan and Metformin(group LM),Pioglitazone(group P),Metformin(group M) and high-fat diet(group O).Twelve LETO rats fed with normal diet served as normal control group(group NC).At forty-eight weeks,morbidity of diabetes,FFA,serum lipids and body weight were observed after twenty-two weeks treated drugs.【Results】 Compared with group O,T2DM was decreased but no statistical significance(P =0.085).T2DM in group LM was significantly lower than group O(P =0.035);Compared with group O,the FFA,TC,TG,LDL were markedly decreased(P =0.040,0.023,0.037 and 0.000,respectively).The body weight of group P was higher than that of rats in other groups(P 0.05).【Conclusion】 Combination of Telmisartan and Metformin can prevent the morbidity of diabetes of OLETF rats fed with high-fat diet and improve FFA,serum lipid disorders,and the body weight keep stable.