Effects of Angiotensin on Increased Body Weight and Dyslipidemia Induced by High-Fat Diet in Rats

OBJECTIVE To investigate influence of RAS on the development of obesity induced with high-fat diet and its possible mechanism.METHODS40 SD rats were randomly divided into four groups(n=10 per group) as following: Group A was fed with standard diet(control group),group B was fed with telmisartan and standard diet(control treated group),group C was fed with high-fat diet(high-fat diet group),group D was fed with telmisartan and high-fat diet(high-fat diet treated group).Body weight was measured before and after the treatment.At 10th week,lipids,FFA and insulin were measured.The expression of adipokines(TNF-α,IL-6,adiponectin,MCP-1 and CD68) in adipose tissue was determined by semi-quantitative RT-PCR.RESULTSThere were significant differences among the four groups in body weight(P=0.002).The increase of body weight was significantly higher in group C than group D(P=0.012).The level of TG was significantly higher in group C than group D(P=0.002).The level of HDL-C was significantly lower in the in group C than group D(P=0.023).High-fat diet had significant effect on the expression level of adiponectin mRNA(P=0.014) and no significant effect on the expression levels of TNF-α,IL-6,adiponectin,MCP-1 and CD68 mRNA(P=0.305;P=0.390;P=0.063;P=0.552;P=0.321,respectively).Telmisartan had no significant effect on the expression levels of TNF-α,IL-6,adiponectin,MCP-1 and CD68 mRNA(P=0.305;P=0.390;P=0.063;P=0.552;P=0.321,respectively).CONCLUSIONTelmisartan treatment for 10 weeks inhibited the increase of body weight induced by high-fat diet,suggesting that AngⅡ is involved in the development of obesity and improved dyslipidemia.