2012•Journal of Taishan Medical CollegeRequires access
The effect of salmeterol fluticasone combined with montelukast on the lung function and immunologic function of children with asthma and the curative effect
Ze-dong Ren
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Abstract
Objective: To explore the effect of salmeterol fluticasone combined with montelukast on the lung function and immunologic function of children with asthma and the curative effect.Methods: One hundred children with asthma were randomly divided into the first treatment group and the second treatment group.The first treatment group were treated with salmeterol fluticasone twice daily for 3 months.The second treatment group were treated with salmeterol fluticasone twice daily and 5mg montelukast before sleep daily for 3 months.The lung function was evaluated,the level of IL-4,INF-γ,IgE,EOS were determined and the score of Asthma Control Test was measured before and after treatment.Results: The lung function was significantly improved in the two groups before treatment than after treatment and the scores of ACT were higher.The lung function was improved more significantly in the first treatment group than in the second treatment group and the scores of ACT were higher after treatment.The level of IL-4,IgE,EOS and IL-4/ IFN-γ were higher in the two groups before treatment than after treatment and the level of IFN-γ was lower.The levels of IL-4,IgE,EOS and IL-4/ IFN-γ were higher in the first treatment group than in the second treatment group and the level of IFN-γ was lower after treatment.Conclusion: Salmeterol fluticasone combined with montelukast can improve lung function,regulate immunity and control asthma more effectively than single salmeterol fluticasone.