Clinical Observation on Analgesic Effects of Wenyangzhitong Capsule to Bony Metastatic Carcinoma

Objective To observe the clinical efficacy of Wenyangzhitong capsule against the pain to bony metastatic carcinoma. Methods 35 patients were first observed by self-cross-over control study, then divided randomly into treatment group and control group. Compare the analgesic efficacy and adverse effects of two groups after being administered. Results In the self-cross-over control study, the efficacy rates of Wenyangzhitong capsule, Indomethacin and placebo were 62.8%, 71.4%, 28.6%, respectively. Both Wenyangzhitong capsule group and Indomethacin group showed significant difference compared with the placebo group (P0.01). The efficacy rates of d3, d7 after treatment were 66.7%, 72.2% in Wenyangzhitong capsule group, and 70.6%, 64.7% of the Indomethacin group. There was no significant difference between them (P0.05). Conclusion Wenyangzhitong capsule is effective against the pain to bony metastatic carcinoma and safe to acute administering.