Clinical significance of determination of indexes of RBC and platelet and coagulation function in patients with hepatic disease

Objective To observe the variations of levels of red blood cell, blood platelets, blood coagulation in hpatopathy patients and their clinical significance. Methods The levels of red blood cell, blood platelet, blood coagulation in 200 hepatopathy patients and 60 healthy people were determined by Sysmex-K-4500 and STA-R. Results The levels of red blood cell count(RBC), hemoglobin concentration(HGB),packed cell volume(PCV),platelet count(PLT)、fibrinogen(FIB) were obviously reduced in hepatopathy patients with acute hepatitis, chronic hepatitis, hepatocirrhosis, liver cancer comparing with the ones in the control group.. Moreover, the value of mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC),red blood cell volume distribution width(RDW%),mean platelet volume(MPV),platelet distribution width(PDW),platelet large cell ratio(P-LCR%),prothrombin time(PT),prothrombin time international normalization ratio(PT-INR),activated partial thromboplasting time(APTT),thrombin time(TT)were obviously increased in hepatopathy patients comparing with the ones in the control group(P0.05 or P0.01). Conclusion There were significant changes of the value of red blood cell, blood platelet and blood coagulation parameters. Furthermore, the changes of the levels of red blood cell, blood platelet, blood coagulation parameters are not only closedly associted with the progression and prognosis of the disease but also are the significant reference indicators for diagnosis of progression and severity of the disease and guiding clinical treatment.