2013•Liaoning Zhongyiyao Daxue xuebaoRequires access

Protective Effect on Kidney and Mechanism of Sanhuang Yishen Capsule in Rats with Diabetes

Chi Xiu

Abstract

Objective:To observe and verify the intervention action of Sanhuang Yishen capsule on kidney in diabetes,and to study its possible mechanism.Methods:Diabetic rats(n=14/group)were randomly divided into diabetes model group,low-dose Sanhuang Yishen capsule treated group[0.4 g/(kg.d)],middle-dose Sanhuang Yishen capsule treated group[0.8 g/(kg.d)],high-dose Sanhuang Yishen capsule treated group[1.6 g/(kg.d)].Ten SD rats were selected as control group.At the end of 8th week,we detected blood glucose,glycosylated hemoglobin,creatinine,urea nitrogen,24 hour urine protein,superoxide dismutase,malondialdehyde and BMI index.Results:8 weeks later,middle-dose,high-dose Sanhuang Yishen capsule treated groups compared with the diabetes model group,BMI index and the level of serum creatinine and urea nitrogen were obviously decreased(P0.01).The MDA content in kidney

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Key concepts: Medicine, Capsule, Creatinine, Internal medicine, Blood urea nitrogen, Diabetes mellitus, Endocrinology, Malondialdehyde