2008•Chinese Journal of Current Advances in General SurgeryRequires access
Effect of simvastatin on the secretion of IL-6 and IL-8 in human umbilical vein endothelial cells
XU He-jie
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Abstract
Objective: To observe the effect of simvastatin on the secretion of IL-6 andIL-8 in human umbilical vein endothelial cells. Method: Human umbilical vein endothelial cells were stimulated by LPS (100 ng/ml)and co-incubated with different concentrations of simvastatin (5 μg/mL,10 μg/mL) for 1-24 hours (1 h,12 h and 24 h). The levels of IL -6 and IL -8 in the cells were measured by ELISA. Result: LPS could increase the production of both IL-6 and IL-8 in umbilical vein endothelial cells significantly . The levels of these cytokines were reduced significantly by simvastatin when compared with blank control group (P0.01). Conclusion: Simvastatin can reduce the levels of IL-6 and IL-8 in the human umbilical vein endothelial cells, which is stimulated by LPS.