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Determination of danshenol in compound danshen extract by HPLC

YU Qiong

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Abstract

Objective To determine the content of danshensu in compound danshen extract with HPLC.Methods Column: Agilent C18(250 mm×4.6 mm,5 μm);mobile phase methanol-1% acetic acid,flow rate:1.0 mL·min-1;temperature:room temperature;and detective wavelength:280 nm.Results Y=11 981 X+11.492(r=0.999 9)linearity range: 20.8～145.6 μg·mL-1.The content of danshenol in compund danshen extract was 58.28 μg·mL-1,and RSD was 0.77% in this group averagely.Recovery was 100.03%.RSD was 0.82%.Conclusion This method could be used as the quality control standard for salvia miltiorrhiza and compound salvia miltiorrhiza preparation.

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Objective To determine the content of danshensu in compound danshen extract with HPLC.Methods Column: Agilent C18(250 mm×4.6 mm,5 μm);mobile phase methanol-1% acetic acid,flow rate:1.0 mL·min-1;temperature:room temperature;and detective wavelength:280 nm.Results Y=11 981 X+11.492(r=0.999 9)linearity range: 20.8～145.6 μg·mL-1.The content of danshenol in compund danshen extract was 58.28 μg·mL-1,and RSD was 0.77% in this group averagely.Recovery was 100.03%.RSD was 0.82%.Conclusion This method could be used as the quality control standard for salvia miltiorrhiza and compound salvia miltiorrhiza preparation.

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Available abstract

Objective To determine the content of danshensu in compound danshen extract with HPLC.Methods Column: Agilent C18(250 mm×4.6 mm,5 μm);mobile phase methanol-1% acetic acid,flow rate:1.0 mL·min-1;temperature:room temperature;and detective wavelength:280 nm.Results Y=11 981 X+11.492(r=0.999 9)linearity range: 20.8～145.6 μg·mL-1.The content of danshenol in compund danshen extract was 58.28 μg·mL-1,and RSD was 0.77% in this group averagely.Recovery was 100.03%.RSD was 0.82%.Conclusion This method could be used as the quality control standard for salvia miltiorrhiza and compound salvia miltiorrhiza preparation.

Key concepts: Salvia miltiorrhiza, Chromatography, Chemistry, High-performance liquid chromatography, Content determination, Quality standard, Recovery rate, Acetic acid

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