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2004•Practical Preventive MedicineRequires access

Expressions of Leukemia Inhibitory Factor and its Receptor Genes in Human Decidua and Chorion

Liu Jei

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Abstract

Objective To study the expressions of leukemia inhibitory factor (LIF) and its receptor (LIFR) gene in the decidua and chorion during early pregnancy. Methods By in situ hybridization and immunohistochemical analysis,the LIFmRNA ,LIF and LIFR protein expressions were observed in 18 cases of human decidua and chorion. Results LIFmRNA ,LIF and LIFR protein expressions were observed in all the decidua and chorionic trophoblast. LIFR immunostaining in chorionic trophoblast is more intensive than that in deciduas. The levels of LIF and LIFR genes expressions were similar in the same specimens. Conclusion The expressions of LIF and LIFR genes in the decidua and/or chorion may be related to embryo implantation,maintenance of placental functions and promotion of embryonic growth.

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What this paper is about

Objective To study the expressions of leukemia inhibitory factor (LIF) and its receptor (LIFR) gene in the decidua and chorion during early pregnancy. Methods By in situ hybridization and immunohistochemical analysis,the LIFmRNA ,LIF and LIFR protein expressions were observed in 18 cases of human decidua and chorion. Results LIFmRNA ,LIF and LIFR protein expressions were observed in all the decidua and chorionic trophoblast. LIFR immunostaining in chorionic trophoblast is more intensive than that in deciduas. The levels of LIF and LIFR genes expressions were similar in the same specimens. Conclusion The expressions of LIF and LIFR genes in the decidua and/or chorion may be related to embryo implantation,maintenance of placental functions and promotion of embryonic growth.

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Available abstract

Objective To study the expressions of leukemia inhibitory factor (LIF) and its receptor (LIFR) gene in the decidua and chorion during early pregnancy. Methods By in situ hybridization and immunohistochemical analysis,the LIFmRNA ,LIF and LIFR protein expressions were observed in 18 cases of human decidua and chorion. Results LIFmRNA ,LIF and LIFR protein expressions were observed in all the decidua and chorionic trophoblast. LIFR immunostaining in chorionic trophoblast is more intensive than that in deciduas. The levels of LIF and LIFR genes expressions were similar in the same specimens. Conclusion The expressions of LIF and LIFR genes in the decidua and/or chorion may be related to embryo implantation,maintenance of placental functions and promotion of embryonic growth.

Key concepts: Leukemia inhibitory factor receptor, Decidua, Leukemia inhibitory factor, Trophoblast, Immunostaining, In situ hybridization, Biology, Immunohistochemistry

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