Relationship between polymorphism of insulin receptor gene Exon 17 with hypertensive nephrosclerosis and renal hypertension

[Objective] To investigate the relationship between polymorphism of insulin receptor(INSR) gene Exon 17 with hypertensive nephrosclerosis and renal hypertension.[Methods] Polymerase chain relation(PCR) combined with single strand conformation polymorphism(SSCP) was used to detect and analyse the NsiI polymorphism of INSR gene Exon 17 in normal renal function of essential hypertension(EH-NRF),renal failure of hypertensive nephroselerosis(EH-CRF),normal renal function of renal hypertension(RH-NRF),renal failure of renal hypertension (RH-CRF) and normal control subjects(NC).[Results] Three different patterns of the PCR products in SSCP,which called band pattern Ⅰ,Ⅱ respectively,were presented in all four patient groups and normal control subject.The mutation frequency of EH-NRF and EH-CRF was remarkblely higher than those of RH-NRF,RH-CRF and NC(P0.05).there was no diference between patients of EH-NRF and EH-CRF.Among the patients of RH-NRF,RH-CRF and NC,there was no diference in frequency of all band pattern.[Conclusions] ①The polymorphism of INSR gene Exon 17 was associated with EH and the mutation frequency of EH was remarkblety higher(band Ⅰ+Ⅱ) than that of RIt.②The polymorphism of INSR gene Exon 17 has unconcern with EH whether complicated by renal damage and with renal damage complicated by hypertension as well.