Apolipoprotein E gene polymorphism with hypertensive renal injury and renal substantial hypertension

ObjectiveTo explore the relationship of the polymorphism of apolipoprotein E gene(ApoE) to hypertensive renal injury and renal substantial hypertension.MethodsBased on PRC technology,we tested the polymorphism of apolipoprotein E gene in 48 patients with hypertension and normal renal function(EH-NRF), 46 with hypertension hypertension and renal failure (EH-CRF), 52 with renal substantial hypertension and normal renal function (RH-NRF), 56 with renal substantial and renal failure (RH-CRF) and 50 normal controls(NC)in Heilongjiang.ResultsThree gene types (the DD,the II and the ID) were detected.D allele and DD which were in EH-NRF and NC had no obvious difference (P0.05). The frequency of D allele and DD was higher in EH-CRF, RH-NRF, RH-CRF than that in EH-NRF, NC, and the difference was significant (P0.05,P0.001).ConclusionsThe I/D polymorphism of ApoE gene has no relationship with EH,but was obviously concerned with the complications of EH,which may play a role in renal injury.D allele may be the genetic risk of renal injury in Han in Heilongjiang.The polymorphism of ACE gene can not account for hypertension,which suggests there exist different genetic elements between hypertension with uremia and uremia with hypertension.