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2006•Acta Academiae Medicinae Qingdao UniversitatisRequires access

INSULIN RECEPTOR GENE POLYMORPHISM ANALYSIS IN RENAL HYPERTENSIVE PATIENTS

Yuhong Xu

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Abstract

Objective To investigate the relationship between polymorphism of insulin receptor(INSR) gene Exon 8 and the etiology of renal hypertension. Methods Polymerase chain reaction(PCR) combined with restriction fragment length polymorphism(RFLP) was used to detect and analyze the polymorphism of INSR gene Exon 8 in 38 renal hypertensive patients with normal renal function(RH-NRF),45 patients complicated by chronic renal failure(RH-CRF) and 38 normal controls(NC).(Results No) polymorphism of NsiⅠ in INSR gene Exon 8 was found to be correlated with renal hypertension in Chinese.N_2 allele frequency of INSR gene had no difference between renal hypertension with or without chronic renal failure(χ~2=0.06,0.08;P(0.05)). Conclusion NsiⅠ polymorphism of INSR gene Exon 8 has no relation with renal hypertension in Chinese.N_2 allele of INSR gene is not the correlated gene of renal hypertension.

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Objective To investigate the relationship between polymorphism of insulin receptor(INSR) gene Exon 8 and the etiology of renal hypertension. Methods Polymerase chain reaction(PCR) combined with restriction fragment length polymorphism(RFLP) was used to detect and analyze the polymorphism of INSR gene Exon 8 in 38 renal hypertensive patients with normal renal function(RH-NRF),45 patients complicated by chronic renal failure(RH-CRF) and 38 normal controls(NC).(Results No) polymorphism of NsiⅠ in INSR gene Exon 8 was found to be correlated with renal hypertension in Chinese.N_2 allele frequency of INSR gene had no difference between renal hypertension with or without chronic renal failure(χ~2=0.06,0.08;P(0.05)). Conclusion NsiⅠ polymorphism of INSR gene Exon 8 has no relation with renal hypertension in Chinese.N_2 allele of INSR gene is not the correlated gene of renal hypertension.

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Available abstract

Objective To investigate the relationship between polymorphism of insulin receptor(INSR) gene Exon 8 and the etiology of renal hypertension. Methods Polymerase chain reaction(PCR) combined with restriction fragment length polymorphism(RFLP) was used to detect and analyze the polymorphism of INSR gene Exon 8 in 38 renal hypertensive patients with normal renal function(RH-NRF),45 patients complicated by chronic renal failure(RH-CRF) and 38 normal controls(NC).(Results No) polymorphism of NsiⅠ in INSR gene Exon 8 was found to be correlated with renal hypertension in Chinese.N_2 allele frequency of INSR gene had no difference between renal hypertension with or without chronic renal failure(χ~2=0.06,0.08;P(0.05)). Conclusion NsiⅠ polymorphism of INSR gene Exon 8 has no relation with renal hypertension in Chinese.N_2 allele of INSR gene is not the correlated gene of renal hypertension.

Key concepts: Exon, Internal medicine, Insulin receptor, Restriction fragment length polymorphism, Gene polymorphism, Polymorphism (computer science), Endocrinology, Medicine

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