Effect of Jiawei Guanlou Xiebai Banxia Decoction on Serum SOD and MDA Levels in Hyperlipidemia Rats

To investigate the effect of Jiawei Guanlou Xiebai Banxia decoction(JWGLBXD)on the levels of serum SOD and MDA in hyperlipidemia rats,and study its therapeutic mechanism in the treatment of hyperlipidemia,the rat models of hyperlipidemia were made by high-fat emulsion intragastric administration.The rats modle were divide into 5groups:model group,JWGLBXD high-dosage group,low-dosage group and the simvastatin group,every groups contain 10rats,another 10healthy SD rats without modeling as the blank group.The lipid parameters,SOD and MDA were detected in rats of each group.Compared with the model group,the levels of TC,TG,LDGL-C and MDA in JWGLBXD high-dosage group and low-dosage group were significantly reduced(P0.05),HDL-C and SOD levels were significantly raised(P0.05).The effect of JWGLBXD high-dosage group on the lipid parameters,the level of serum adiponectin in rats is almost equivalent to that in simvastatin group.This study revealed that JWGLBXD can treat hyperlipidemia effectively and this mechanism may be associated with that JWGLBXD can raise the level of SOD and decrease MDA through lowering blood lipid level.