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Expression of Ang-2/Tie2 and its relation with angiogenesis in breast carcinoma

Seng Jingjing

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Abstract

OBJECTIVE:To study the expressions of Ang-2 and Tie2 in breast cancer and the relation with invasion and metastasis.MEHTODS: The immunohistochemical technique SP was used to detect the Ang-2,Tie2 and MVD which was marked by CD34 in 42 cases of breast cancer,16 cases of breast fibroadenoma and 13 cases of normal breast,the associations between their expressions and the features of clinical pathology of invasive ductal breast carcinoma were also analyzed.RESULTS: The positive rates of Ang-2 and Tie2 in malignant breast tumor were 95.2% and 92.9%,much higher than those in normal breast and breast fibroadenoma which were 15.4%,15.4% and 12.5%,12.5%,P=0.001.There were close correlations between Ang-2 and CD34,Tie2 and CD34.CONCLUSIONS: Angiogenesis is enhanced in breast carcinoma.Ang-2/Tie2 may play a critical role in promoting tumor angiogenesis and progression in human breast carcinoma.

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OBJECTIVE:To study the expressions of Ang-2 and Tie2 in breast cancer and the relation with invasion and metastasis.MEHTODS: The immunohistochemical technique SP was used to detect the Ang-2,Tie2 and MVD which was marked by CD34 in 42 cases of breast cancer,16 cases of breast fibroadenoma and 13 cases of normal breast,the associations between their expressions and the features of clinical pathology of invasive ductal breast carcinoma were also analyzed.RESULTS: The positive rates of Ang-2 and Tie2 in malignant breast tumor were 95.2% and 92.9%,much higher than those in normal breast and breast fibroadenoma which were 15.4%,15.4% and 12.5%,12.5%,P=0.001.There were close correlations between Ang-2 and CD34,Tie2 and CD34.CONCLUSIONS: Angiogenesis is enhanced in breast carcinoma.Ang-2/Tie2 may play a critical role in promoting tumor angiogenesis and progression in human breast carcinoma.

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Available abstract

OBJECTIVE:To study the expressions of Ang-2 and Tie2 in breast cancer and the relation with invasion and metastasis.MEHTODS: The immunohistochemical technique SP was used to detect the Ang-2,Tie2 and MVD which was marked by CD34 in 42 cases of breast cancer,16 cases of breast fibroadenoma and 13 cases of normal breast,the associations between their expressions and the features of clinical pathology of invasive ductal breast carcinoma were also analyzed.RESULTS: The positive rates of Ang-2 and Tie2 in malignant breast tumor were 95.2% and 92.9%,much higher than those in normal breast and breast fibroadenoma which were 15.4%,15.4% and 12.5%,12.5%,P=0.001.There were close correlations between Ang-2 and CD34,Tie2 and CD34.CONCLUSIONS: Angiogenesis is enhanced in breast carcinoma.Ang-2/Tie2 may play a critical role in promoting tumor angiogenesis and progression in human breast carcinoma.

Key concepts: Angiogenesis, Angiopoietin receptor, Breast cancer, Fibroadenoma, Breast carcinoma, CD34, Breast Fibroadenoma, Medicine

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Expression of Ang-2/Tie2 and its relation with angiogenesis in breast carcinoma — Research Paper | ScholarLens