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2005•Zhongguo quanke yixueRequires access

The Effect of SNP on the Content of NO,SOD,MDA in Lead-treated Mouse Brain

Feng Qin-xi

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Abstract

Objective To observe the effect of SNP (a sort of No donor drugs) on the content of nitric oxide (NO),Super oxide dismutase (SOD) and malondialdehyde (MDA) in lead-treated mouse brain.Methods Creating the lead exposure model of mouse by feeding PbAc for four weeks,we dynamically observed the levels of NO,SOD,MDA in lead-treated mouse brain at 3h,12h and 24h after injecting Sodium nitroprusside (SNP).Results In the experimental group,the NO content increased,SOD activity increased and MDA content decreased,and there are significant differences in the level of NO,SOD,MDA between SNP group and lead-treaded model group(P0.01).Conclusion The SNP can protect the damage of brain in lead-treated mouse.

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What this paper is about

Objective To observe the effect of SNP (a sort of No donor drugs) on the content of nitric oxide (NO),Super oxide dismutase (SOD) and malondialdehyde (MDA) in lead-treated mouse brain.Methods Creating the lead exposure model of mouse by feeding PbAc for four weeks,we dynamically observed the levels of NO,SOD,MDA in lead-treated mouse brain at 3h,12h and 24h after injecting Sodium nitroprusside (SNP).Results In the experimental group,the NO content increased,SOD activity increased and MDA content decreased,and there are significant differences in the level of NO,SOD,MDA between SNP group and lead-treaded model group(P0.01).Conclusion The SNP can protect the damage of brain in lead-treated mouse.

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Available abstract

Objective To observe the effect of SNP (a sort of No donor drugs) on the content of nitric oxide (NO),Super oxide dismutase (SOD) and malondialdehyde (MDA) in lead-treated mouse brain.Methods Creating the lead exposure model of mouse by feeding PbAc for four weeks,we dynamically observed the levels of NO,SOD,MDA in lead-treated mouse brain at 3h,12h and 24h after injecting Sodium nitroprusside (SNP).Results In the experimental group,the NO content increased,SOD activity increased and MDA content decreased,and there are significant differences in the level of NO,SOD,MDA between SNP group and lead-treaded model group(P0.01).Conclusion The SNP can protect the damage of brain in lead-treated mouse.

Key concepts: Malondialdehyde, Sodium nitroprusside, SNP, Nitric oxide, Medicine, Superoxide dismutase, Lead (geology), Dismutase

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