Clinical significance of expression of nm23-H1,MMP-2 and TIMP-2 in bladder carcinoma

Objective To investigate the reationship of the expressions of nm23-H1,MMP-2 and TIMP-2 in bladder carcinoma and thier clinical significane.Methods Immunohistochemical study on nm23-H1,MMP-2 and Timp-2 were performed on 69 samples of bladder transitional cell carcinoma of paraffin-embedded specimens of surgical carcinoma.Results There was significant difference in nm23-H1 and MMP-2 between bladder transitional cell carcinoma and normal bladder epithelium(P0.01).The positive expression of nm23-H1 was decreased with the staging,grading and metastasis(P0.05).But the positive expression of MMP-2 was significantly increased with staging and grading(P0.05).Furthermore,the positive rate of MMP-2 was increased in tumor diameter greater than 2 cm,which showed statistical significance(P0.05).The positive expression of TIMP-2 was decreased with the staging and grading and the expression intensity of TIMP-2 was increased with staging and grading,but their was not showed statistical significance.Conclusion The expression of some metastasis-related genes can be used to estimite the metastatic potenciality and help for the adjuvant treatment.