Distribution characteristics of pathogens and drug resistance analysis

OBJECTIVE To investigate the antibiotic resistance and distribution of pathogens isolated from the hospitalized patients and guide the rational use of antimicrobials.METHODS The bacterial identification and antibiotic susceptibility testing were carried out by using MicroScan AutoScan-40 system and testing for ESBLs and MRSA;the data were analyzed by WHONET 5 software.RESULTS Of 1439 clinical isolates,totally 965(67.1%) gram-negative bacilli were isolated,mainly including Escherichia coli,Klebsiella pneumoniae,Acinetobacter spp,and P.aeruginosa;the detection rates of ESBLs-producing E.coli and K.pneumoniae strains were 55.3 % and 32.8%,respectively;gram-negative bacilli were resistant to most antibiotics;there were 223(15.5%) strains of gram-positive cocci detected,mainly including Staphylococcus aureus,coagulase-negative Staphylococci,Enterococcus,and Staphylococcus,the resistance rate of Enterococcus was high,and no vancomycin-resistant strains were identified;there were 251(17.4 %) strains of fungi isolated,among which Candida albicans was dominant.CONCLUSION There are various species of clinical isolates with the high drug resistance rates,gram-negative bacteria are predominant pathogens,and the infections caused by gram-positive cocci and fungi keep an increasingly upward tendency;it is necessary to attach great importance to the etiology examination and the reasonable use of antibiotics on the basis of drug susceptibility testing so as to decrease the drug resistance.