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Association between polymorphism of MBL gene with susceptibility to tuberculosis in Han Population in Xinjiang

Zhang Wan-jiang

Open publisher page 4 citations

Abstract

The aim of the present study was to explore the association between genetic polymorphism of MBL and susceptibility to pulmonary tuberculosis in Xinjiang Han population.A case-control study was conducted to genotype for H/L、P/Q and A/B SNPs in MBL gene from 231 patients with tuberculosis in Xinjiang Province using the sequence-specific polymerase chain reaction(PCR-SSP).Gene frequency(f) and odds ratio(OR) were calculated and the result were compared with those of 226 health individuals.Results indicated that the frequency of HLA-AA homozygote genotype in the group of control was significantly higher than that in the group with tuberculosis(χ2=4.576,OR=0.613,P0.05);and the frequency of HLA-AB in the group with tuberculosis was significantly higher than that in the control group(χ2= 4.821,OR=1.673,P0.05).The results showed that HLA-AA homozygote genotype was evidently uncorrelated to the incidence of tuberculosis disease.It was probably a protected gene in tuberculosis for Han population in Xinjiang.Furthermore,as HLA-AB evidently correlated to the incidence of tuberculosis,it might be a susceptible gene in tuberculosis for Han population in Xinjiang.

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What this paper is about

The aim of the present study was to explore the association between genetic polymorphism of MBL and susceptibility to pulmonary tuberculosis in Xinjiang Han population.A case-control study was conducted to genotype for H/L、P/Q and A/B SNPs in MBL gene from 231 patients with tuberculosis in Xinjiang Province using the sequence-specific polymerase chain reaction(PCR-SSP).Gene frequency(f) and odds ratio(OR) were calculated and the result were compared with those of 226 health individuals.Results indicated that the frequency of HLA-AA homozygote genotype in the group of control was significantly higher than that in the group with tuberculosis(χ2=4.576,OR=0.613,P0.05);and the frequency of HLA-AB in the group with tuberculosis was significantly higher than that in the control group(χ2= 4.821,OR=1.673,P0.05).The results showed that HLA-AA homozygote genotype was evidently uncorrelated to the incidence of tuberculosis disease.It was probably a protected gene in tuberculosis for Han population in Xinjiang.Furthermore,as HLA-AB evidently correlated to the incidence of tuberculosis,it might be a susceptible gene in tuberculosis for Han population in Xinjiang.

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Available abstract

The aim of the present study was to explore the association between genetic polymorphism of MBL and susceptibility to pulmonary tuberculosis in Xinjiang Han population.A case-control study was conducted to genotype for H/L、P/Q and A/B SNPs in MBL gene from 231 patients with tuberculosis in Xinjiang Province using the sequence-specific polymerase chain reaction(PCR-SSP).Gene frequency(f) and odds ratio(OR) were calculated and the result were compared with those of 226 health individuals.Results indicated that the frequency of HLA-AA homozygote genotype in the group of control was significantly higher than that in the group with tuberculosis(χ2=4.576,OR=0.613,P0.05);and the frequency of HLA-AB in the group with tuberculosis was significantly higher than that in the control group(χ2= 4.821,OR=1.673,P0.05).The results showed that HLA-AA homozygote genotype was evidently uncorrelated to the incidence of tuberculosis disease.It was probably a protected gene in tuberculosis for Han population in Xinjiang.Furthermore,as HLA-AB evidently correlated to the incidence of tuberculosis,it might be a susceptible gene in tuberculosis for Han population in Xinjiang.

Key concepts: Tuberculosis, Genotype, Biology, Single-nucleotide polymorphism, Odds ratio, Population, Genotype frequency, Allele frequency

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