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2013•Chinese Journal of Health Laboratory TechnologyRequires access

A preliminary study on relevance of HLA-A gene and tuberculosis

Jie Ding

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Abstract

Objective:To investigate the association between the polymorphism of HLA-A gene and susceptibility to tuberculosis in Jiangsu Han population.Methods: One hundred and thirty-eight patients with tuberculosis were tested for the HLA-A gene using the polymerase chain reaction with sequence specific primer(PCR-SSP)technique,and the results were compared with those of 100 healthy individuals.Antigenic frequency and genetic frequency were compared and Odds Ratio was calculated.Results: The frequency of HLA-A30 in the group with tuberculosis disease is significantly higher than that in the group of healthy control(χ2=7.480,P=0.006,OR=3.060).Conclusion: The results showed that HLA-A30 was probably susceptible gene in tuberculosis for Jiangsu Han population.

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What this paper is about

Objective:To investigate the association between the polymorphism of HLA-A gene and susceptibility to tuberculosis in Jiangsu Han population.Methods: One hundred and thirty-eight patients with tuberculosis were tested for the HLA-A gene using the polymerase chain reaction with sequence specific primer(PCR-SSP)technique,and the results were compared with those of 100 healthy individuals.Antigenic frequency and genetic frequency were compared and Odds Ratio was calculated.Results: The frequency of HLA-A30 in the group with tuberculosis disease is significantly higher than that in the group of healthy control(χ2=7.480,P=0.006,OR=3.060).Conclusion: The results showed that HLA-A30 was probably susceptible gene in tuberculosis for Jiangsu Han population.

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Available abstract

Objective:To investigate the association between the polymorphism of HLA-A gene and susceptibility to tuberculosis in Jiangsu Han population.Methods: One hundred and thirty-eight patients with tuberculosis were tested for the HLA-A gene using the polymerase chain reaction with sequence specific primer(PCR-SSP)technique,and the results were compared with those of 100 healthy individuals.Antigenic frequency and genetic frequency were compared and Odds Ratio was calculated.Results: The frequency of HLA-A30 in the group with tuberculosis disease is significantly higher than that in the group of healthy control(χ2=7.480,P=0.006,OR=3.060).Conclusion: The results showed that HLA-A30 was probably susceptible gene in tuberculosis for Jiangsu Han population.

Key concepts: Tuberculosis, Human leukocyte antigen, Primer (cosmetics), Polymerase chain reaction, Odds ratio, Allele frequency, Gene, Immunology

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