Correlation between the polymorphism of HLA-DRB1 gene and the susceptibility to pulmonary tuberculosis in population of Uygur Nationality in Xinjiang.

The aim of this study was to explore the association between polymorphism of HLA-DRB1 gene and the susceptibility to pulmonary tuberculosis in population of Uygur Nationality. In this case-control study,HLA-DRB1 genes from 226 PTB cases and 231 controls among Uygur Nationality in Xinjiang area were typed by polymerase chain reaction-sequence specific primers (PCR-SSP)and gene frequency (GF),then the odds ratio (OR) were calculated and compared. The frequency of HLA-DRB1*11 gene in pulmonary tuberculosis cases was significantly higher than that in the healthy controls (OR=4.388,χ2=9.872,Pc=0.0260.05),and their GFs were 4.53% and 1.09% respectively. The frequency of HLA-DRB1*04 gene in pulmonary tuberculosis cases was also significantly higher than that in the healthy controls and their GFs were 12.77% and 8.36%,but the difference was not statistically significant (Pc0.05). Results indicate that HLA-DRB1*11 alleles were evidently correlated to the incidence of tuberculosis disease and DRB1*11 alleles might be the susceptible genes of tuberculosis disease in population of Xinjiang Uygur Nationality.