Effect of Juli Sanjie Pill on Estrogen Receptor Expression in the Tissue of Hysteromyoma

Objective To observe the effect of Juli Sanjie Pill(JSP) on estrogen receptor(ER)α and ERβ expression in the myometrium and hysteromyoma tissue,and to explore the correlation of ERα and ERβ expression levels with the incidence of hysteromyoma. Methods Forty hysteromyoma patients were divided into two groups: 20 patients with operative indications after oral use of JSP and asking for operation,were enrolled in the treatment group,and other 20 patiens without mediation of medicine but asking for operation were in the control group.The ERα and ERβ expression levels in hysteromyoma tissue and the surrounding normal myometrium of the two groups were detected by radioimmunoassay.Results There presented the expression of ERα and ERβ in the hysteromyoma tissue and the surrounding normal myometrium of the two groups,and the levels in the hysteromyoma tissue were higher than that in the myometrium(P0.01).The ERα expression level in hysteromyoma tissue and myometrium was higher than ERβ level(P0.05).In the treatment group,ERα and ERβ expression levels in hysteromyoma tissue were lower than those in the control group(P0.01),and the expression level of ERα was lower in the myometrium than that in the controlgroup(P0.05),but the difference of ERβ expression level in the myometrium of the two groups was insignificant(P0.05).Conclusion The incidence of hysteromyoma is correlated with the local expression of ERα and ERβ in the uterus.The therapeutic mechanism of JSP for hysteromyoma is probably related with the decrease of ERα and ERβ expression levels in hysteromyoma tissue and with the decrease of ERα level in the surrounding normal myometrium.