A Study about the Expression of IGFBP-3、ER and PR in Hysteromyoma

Objective To explore the relationship between insulin-like growth factor binding protein-3(IGFBP-3),estrogen receptor(ER),progesterone receptor(PR) and hysteromyoma.Methods The IGFBP-3,ER,PR in the serum of 38 patients with hysteromyoma and 32 healthy women were detected by enzyme linked immonosorbent assay(ELISA)and chemiluminescent immunoassays respectively,the expressions of IGFBP-3,ER and PR in leiomyoma tissue and myometrium 38 patients with hysteromyoma after hysterectomy were detected by immunohistochemistry.Results The serum level of IGFBP-3 was significantly lower than that of healthy controls(P0.05),while the serum levels of ER and PR showed no difference.The IGFBP-3 expression in leiomyoma tissue was lower than that of myometrium(P0.05).However,the expression of ER and PR in leiomyoma were both significantly higher than that of myometrium(P0.05).There was a negative correlation between IGFBP-3 and ER in leiomyoma tissue(P0.05)and there was a positive correlation between the concentration of IGFBP-3 in serum and its intensity of expression in leiomyoma tissue(P0.05).Conclusion Low expression of IGFBP-3 and the overexpression of ER and PR in hysteromyoma may be correlated with the occurrence and development of hysteromyoma.Regulation of IGFBP-3,ER and PR may become the research direction of etiological treatment in hysteromyoma.