A comparative analysis of 10-day sequential and 7-day triple therapy on eradication of Helicobacter pylori

Objective:To evaluate the effect and safety of 10-day sequential therapy consisted of pantoprazole,clarithromycin,amoxicillin and tinidazole,and 7-day triple therapy in eradicating Helicobacter pylori(Hp)infection.Methods:One hundred and five patients of peptic ulcer and chronic gastritis with Hp-positive were randomly divided into two groups.Ten-day sequential treatment group(53 cases)was pantoprazole 40 mg,amoxicillin 1 000 mg,orally two times a day in first five days,then pantoprazole 40 mg,clarithromycin 500 mg,tinidazole 500 mg,orally two times a day in the second five days.Seven-day triple treatment group(52 cases)was pantoprazole 40 mg,clarithromycin 500 mg and amoxicillin 1 000 mg,orally two times a day for seven days.Results:The eradication rate of 10-day sequential therapy was 90.6%,and the eradication rate of 7-day triple therapy was 71.2%,the result showed a significant difference(P0.05).The incidence rates of adverse reaction in 10-day sequential therapy group(18.9%)and 7-day triple therapy group(17.3%)were similar(P0.05).Conclusion:The 10-day sequential therapy including pantoprazole,amoxicillin,clarithromycin and tinidazole was more effective than 7-day triple therapy on eradication of Hp infection.