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2002•Zhejiang Medical JournalRequires access

The expression of α-SMA and TGF-β_1 in renal tissue of rats with tubulointerstitial fibrosis

Xiaoxia Chen

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Abstract

Objective To study the role of tubular epithelial-myofibroblast transdifferentiation in pathogenesis of renal interstitial fibrosis.Methods Immunohistochemistry staining was used to investigate the pathological change of kidney and the expression of α-smooth muscular actin(α-SMA) and transforming growth factor β1(TGF-β1) in renal tissue of rats with unilateral urethral obstruction (UUO).Results The levels of expression of α-SMA and TGF-β1 on the 14th day and 28th day in kidney of UUO were significantly higher than that of normal rats(P0.05).Conclusion α-SMA may be used as a marker of the tubular epithelial-myofibroblast transdifferentitiation;TGF-β1 may play an important role in pathogenesis of renal interstitial fibrosis.

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What this paper is about

Objective To study the role of tubular epithelial-myofibroblast transdifferentiation in pathogenesis of renal interstitial fibrosis.Methods Immunohistochemistry staining was used to investigate the pathological change of kidney and the expression of α-smooth muscular actin(α-SMA) and transforming growth factor β1(TGF-β1) in renal tissue of rats with unilateral urethral obstruction (UUO).Results The levels of expression of α-SMA and TGF-β1 on the 14th day and 28th day in kidney of UUO were significantly higher than that of normal rats(P0.05).Conclusion α-SMA may be used as a marker of the tubular epithelial-myofibroblast transdifferentitiation;TGF-β1 may play an important role in pathogenesis of renal interstitial fibrosis.

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Available abstract

Objective To study the role of tubular epithelial-myofibroblast transdifferentiation in pathogenesis of renal interstitial fibrosis.Methods Immunohistochemistry staining was used to investigate the pathological change of kidney and the expression of α-smooth muscular actin(α-SMA) and transforming growth factor β1(TGF-β1) in renal tissue of rats with unilateral urethral obstruction (UUO).Results The levels of expression of α-SMA and TGF-β1 on the 14th day and 28th day in kidney of UUO were significantly higher than that of normal rats(P0.05).Conclusion α-SMA may be used as a marker of the tubular epithelial-myofibroblast transdifferentitiation;TGF-β1 may play an important role in pathogenesis of renal interstitial fibrosis.

Key concepts: Myofibroblast, Transdifferentiation, Medicine, Pathogenesis, Immunohistochemistry, Transforming growth factor, Pathology, SMA*

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The expression of α-SMA and TGF-β_1 in renal tissue of rats with tubulointerstitial fibrosis — Research Paper | ScholarLens