ScholarLens Back to search
2009•Zhongguo laonianxue zazhiRequires access

Effect of Safflower on tubular epithelial-myofibroblast transdifferentiation in renal interstitial fibrosis rats

Qing Xu

Open publisher page 1 citations

Abstract

Objective To observe the effect of Safflower on tubular epithelial-myofibroblast transdifferentiation in renal interstitial fibrosis rats induced with unilateral ureteral obstruction (UUO). Methods Renal interstitial fibrosis rats induced with UUO were given orally Safflower(4.0 g·kg-1·d-1) and Valsartan (10 mg·kg-1·d-1) respectively. The marker of epithelial-myofibroblast transdifferentiation α-smooth muscular actin (α-SMA) and collagen Ⅲ were examined by immunohistochemical method and in situ hybridization. Results The positive area and density ofα-SMA and collagen Ⅲ in UUO rats increased markedly than those in sham operation group and could be inhibited by Safflower and Valsartan. Conclusions Safflower can antagonize renal interstitial fibrosis by inhibition of epithelial-myofibroblast transdifferentiation.

About this research paper

What this paper is about

Objective To observe the effect of Safflower on tubular epithelial-myofibroblast transdifferentiation in renal interstitial fibrosis rats induced with unilateral ureteral obstruction (UUO). Methods Renal interstitial fibrosis rats induced with UUO were given orally Safflower(4.0 g·kg-1·d-1) and Valsartan (10 mg·kg-1·d-1) respectively. The marker of epithelial-myofibroblast transdifferentiation α-smooth muscular actin (α-SMA) and collagen Ⅲ were examined by immunohistochemical method and in situ hybridization. Results The positive area and density ofα-SMA and collagen Ⅲ in UUO rats increased markedly than those in sham operation group and could be inhibited by Safflower and Valsartan. Conclusions Safflower can antagonize renal interstitial fibrosis by inhibition of epithelial-myofibroblast transdifferentiation.

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To observe the effect of Safflower on tubular epithelial-myofibroblast transdifferentiation in renal interstitial fibrosis rats induced with unilateral ureteral obstruction (UUO). Methods Renal interstitial fibrosis rats induced with UUO were given orally Safflower(4.0 g·kg-1·d-1) and Valsartan (10 mg·kg-1·d-1) respectively. The marker of epithelial-myofibroblast transdifferentiation α-smooth muscular actin (α-SMA) and collagen Ⅲ were examined by immunohistochemical method and in situ hybridization. Results The positive area and density ofα-SMA and collagen Ⅲ in UUO rats increased markedly than those in sham operation group and could be inhibited by Safflower and Valsartan. Conclusions Safflower can antagonize renal interstitial fibrosis by inhibition of epithelial-myofibroblast transdifferentiation.

Key concepts: Transdifferentiation, Myofibroblast, Valsartan, Fibrosis, Pathology, Kidney, Medicine, Endocrinology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Safflower on tubular epithelial-myofibroblast transdifferentiation in renal interstitial fibrosis rats — Research Paper | ScholarLens