Study on the expression of vascular endothelial growth factor and microvessei density in endometrial carcinoma

Objective:To investigate the expression of Vascular Eedometrial Growth Factor (VEGF) and angiogenesis in endometrial car- cinoma and its relation to the clinico-pathological parameters.Methods:50 specimens of endometrial carcinoma and 20 normal endometria were studied by S-P immunohistological technique,using ployclonal antibodies against VEGF to examine the expression of VEGF and Microvessel Density (MVD).Results:Positive expression rate of VEGF(92%) in endometrial carcinoma is higher than that(30%) in normal endometrium (p＜0.01).MVD(46.0±4.5) in endometrial carcinoma is higher than that(14.0±1.7) in normal endometrium(P＜0.05).MVD(69.94±16.8) in deep myometrial invasion group is higher than that(42.8±4.4) in non-deep myometrial invasion group (P＜0.05).Conclusion: VEGF and MVD are both associated with the genesis d endometrial carcinoma,which depends on vascularization.So MVD can be considered as the prognosis factor of endometrial carcinima.