Relationship between the expression of HIF-1α,VEGF and microvessel density in endometrial carcinoma tissues

OBJECTIVE:To study the expression of hypoxia-inducible factor-1alpha,vascular endothelial growth factor and its receptor KDR,microvessel density in endometrial carcinoma and investigate the impacts of them.METHODS:Expression of HIF-1α,VEGF and KDR were analyzed by immunonistochemisitry and MVD was determined by CD34 immunostaininy in 39 cases of endometrial carcinoma,18 cases of endometrial hyperplasia and 17 cases of normal endometrium.RESULTS:HIF-1α,VEGF,KDR were overexpressed in endometrial carcinoma.Positive expression of HIF-1α,VEGF,KDR and MVD was higher in endometrial carcinoma than those in endometrial hyperplasia and normal endometrium tissues,P0.05.The expressions of HIF-1α,VEGF and KDR were increasing of clinical staging.There was significant stage Ⅰ and stage Ⅱ-Ⅳ(P=0.014 9).CONCLUSIONS:The expression of HIF-1α,VEGF,KDR and MVD are increasing from normal endometrium,endometrial hyperplasia through endometrial carcinoma.In total,the results clue on the important role of HIF-1α,VEGF,KDR and MVD in the development of endometrial carcinoma.Additional they are treated as endometrial carcinoma potential invasive tumor markers.