Effect of supplementary Sijunzi decoction on prevention of N-methyl-N'-nitro-N-nitrosoguanidine induced gastric cancer in rat model

[Objective]To observe the effect of supplementary Sijunzi decoction(SSD) on the prevention of N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) induced gastric cancer in the rat model,and investigate the relationship between development of gastric cancer and syndrome of spleen deficiency and blood stasis.[Methods] Ninety male Wister rats were randomly divided into five groups(n=18,each):the normal control group,the model group(induced by MNNG),the SSD group,the Zengye decoction(ZD)group and the 0.85% saline group.The lesions of gastric mucosa were observed after the rats were fed(28±2) weeks.[Results] Eighty-three rats(92.2%)completed the study.The incidence of gastric cancer in the model group was 40.0%(6/15),which was higher than that in the SSD group of 5.9%(1/17)(P0.05).The incidence of gastric mucosal atrophy,intestinal metaplasia and dysplasiain the model group was higher thanthat inthe SSDgroup respectively(P0.05).There was nosignificant differenceintheincidence of gastric cancer,mucosal atrophy,intestinal metaplasia anddysplasia between the model group and the ZDgroup or the 0.85 %sali me group(P0.05).Nocancer occurredinthe normal control group.[Conclusion]Spleen deficiency and blood stasisis oneof the i mportant factors in the occur and development of gastric cancer and precancerous lesions.SSDcan effectively prevent MNNGinduced gastric cancer in the rat model.