2014•Hainan Yixueyuan xuebaoRequires access

Effect of glycocine on acute lung injury of the severe acute pancreatitis in rats

Weifen Chen

Abstract

Objective:To investigate the effect of glycocine on acute lung injury induced by the severe acute pancreatitis in rats.Methods:The rats were randomly divided into three groups:sham operation rats(group A),severe acute pancreatitis group(group B)and SAP rats given the glycocine(group C).The SAP model was established by injecting 5% sodium taurocholate into biliopancreatic ducts with needle.The glycocine group was injected with glycocine through vena caudalis at 3h,6hbefore the SAP model induced.Rats in each group were sacrificed at 6h,12h,24hafter sham operation or SAP.The concentrations of HMGB-1were measured by ELISA,TREM-1mRNA expressions were measured by RTPCR.Results:Compared with group A,the levels of HMGB-1and the expressions of TREM-1mRNA in group B were significantly elevated(P0.05).In group C,these items were lower than that of group B(P0.05).Conclusions:Glyine can decrease the expression of TREM-1mRNA and HMGB1,then can be used for treatment of severe acute pancreatitis.

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Available abstract

Key concepts: Medicine, Acute pancreatitis, Group B, Group A, HMGB1, Pancreatitis, Gastroenterology, Internal medicine